Retrovirus-Induced Ovine Pulmonary Adenocarcinoma, an Animal Model for Lung Cancer
نویسندگان
چکیده
منابع مشابه
Retrovirus-induced ovine pulmonary adenocarcinoma, an animal model for lung cancer.
Studies on the molecular mechanisms of transformation of retrovirus-induced neoplasms in domestic and laboratory animal species have provided insights into the genetic basis of cancer. Ovine pulmonary adenocarcinoma (OPA) is a retrovirus-induced spontaneous lung tumor of sheep that has striking analogies to some forms of human adenocarcinoma. The etiologic agent of OPA, jaagsiekte sheep retrovi...
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Ovine pulmonary adenocarcinoma (OPA) is an infectious lung tumor of sheep caused by Jaagsiekte sheep retrovirus (JSRV). To test the hypothesis that JSRV insertional mutagenesis is involved in the oncogenesis of OPA, we cloned and characterized 70 independent integration sites from 23 cases of OPA. Multiple integration sites were identified in most tumors. BLAST analysis of the sequences did not...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2001
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/93.21.1603